Notes from Dr. Baumgarner for Friday's breakout

Phenobarbital:

unionized is better reabsorbed than ionized
Txt considerations
Given with Na Bicarb to increase urine ph and decrease reabsorption of drug
Given with activated charcoal to prevent enterohepatic recycling from biliary excretion
Hydrate pt

Ampicillin:

218.7 is the total clearance
Health dept. often gives 3.5 g amp and 1 g probencid in one time dose to treat gonorrhea